时间:2024-09-20 10:58:51 来源:网络整理编辑:時尚
Scientists have made an early but important development in the fight against HIV.。For the first time
Scientists have made an early but important development in the fight against HIV.。
For the first time, a team of researchers has shown that they can remove HIV type 1 (HIV-1) from infected mouse cells using a powerful gene-editing tool. By removing DNA of the deadly virus in rodents, they also stopped the virus from replicating. 。
While a permanent cure for HIV in humans remains a ways off, the new study is a major step toward achieving that goal, according to scientists at the University of Pittsburgh and Temple University's Lewis Katz School of Medicine. 。
SEE ALSO:Scientists see early progress on potential HIV cure 。SEE ALSO:Scientists see early progress on potential HIV cure。 The journal 。 Molecular Therapy 。
published the team's findings on Wednesday.。
"The next stage would be to repeat the study in primates," Kamil Khalili, a co-author of the study who chairs Temple's neuroscience department, said in a press release. "Our eventual goal is a clinical trial in human patients." 。Credit: molecular therapy 。
For their study, researchers used CRISPR/Cas9, a tool that enables scientists to edit parts of the genome -- our full genetic material -- by removing, adding, or altering sections of the DNA sequence. 。
By signing up you agree to our Terms of Use and Privacy Policy.。
Thanks for signing up!。
The new work builds on an earlier proof-of-concept study that involved genetically modified, or "transgenic," mice and rats. After incorporating the DNA of HIV-1 into the genome of every tissue of the animals' bodies, the team found it could delete targeted fragments of HIV-1 from the genome in most tissues. 。
"Our new study is more comprehensive," Wenhui Hu, a co-author and associate professor of pathology at Temple, said in the news release. He noted the team has "improved the efficiency" of their approach this time by adding two mouse models.。In the first model, researchers again used transgenic mice to confirm their previous findings. The team genetically inactivated HIV-1 in the mice, thus reducing the RNA expression of viral genes by 60 to 95 percent. That means they stopped RNA, which act as a genetic messenger, from relaying the toxic information.。
A scientist in China worker performs an HIV test at a lab in Shanghai.Credit: china photos/Getty Images 。
For the two other models, scientists studied mice with actively replicating HIV infections and mice with latent infections that lie dormant within the cells. 。
Mice with active infections had EcoHIV, the mouse equivalent of human HIV-1. Using CRISPR/Cas9, researchers were able to block replication of the virus and show they could potentially prevent systemic infection -- marking the first evidence that this method can eradicate the virus.。
For the latent infections, the team studied "humanized" mice that had been engrafted with human immune cells, including T cells. (People with HIV/AIDS have a devastatingly low number of a particular type of T cell.) The mice were also infected with latent HIV-1.。
Featured Video For You。
Featured Video For You 。
Nate Parker is finally thinking about the woman who accused him of rape2024-09-20 10:29
FIFA23數據 :姆巴佩91範迪克90 皇馬尤文鋒霸暴漲2024-09-20 10:05
梅西天秀操作 !挑球過人+致命直傳 慘遭姆皇吐餅2024-09-20 10:00
後金元時代的廣州德比,一對難兄難弟 活著比勝負更有意義2024-09-20 09:53
Wikipedia co2024-09-20 09:46
李鐵取代萊科執教海港?媒體人 :暫時沒有這方麵的信息2024-09-20 08:55
試水突圍足協禁令 ?河北隊遷址山西大同 拎包入住穩賠不賺2024-09-20 08:49
恥辱 !利物浦遭受隊史歐冠第2慘案 首次遇02024-09-20 08:42
Uber's $100M settlement over drivers as contractors may not be enough2024-09-20 08:38
馬寧被撞傷後複出,將出任廣州城VS天津津門虎主裁2024-09-20 08:28
Tributes flow after death of former Singapore president S.R. Nathan2024-09-20 10:55
重返韓國國家隊 ,孫準浩出戰世界杯希望大增 山東隊衛冕懸了?2024-09-20 10:52
巴爾加斯完成海港首堂訓練課 與武磊開心合影2024-09-20 10:48
中超官方 :因疫情防控壓力 中超第16輪5場比賽延期2024-09-20 09:50
Darth Vader is back. Why do we still care?2024-09-20 09:37
後金元時代的廣州德比,一對難兄難弟 活著比勝負更有意義2024-09-20 09:37
國安新帥斯坦利首秀以穩為主 休息一周之後禦林軍會有變換嗎?2024-09-20 09:36
巴爾加斯完成海港首堂訓練課 與武磊開心合影2024-09-20 09:25
Early Apple2024-09-20 09:09
歐冠萌新陣:藥廠王中王迎首秀 皇馬巴薩新援可期2024-09-20 08:36