时间:2025-04-26 20:49:43 来源:网络整理编辑:探索
Scientists are finding more evidence that you should probably cut down on your sugar intake.。 A grou
Scientists are finding more evidence that you should probably cut down on your sugar intake.。
A group of U.K. researchers say they've spotted the molecular "tipping point" that could explain sugar's ties to Alzheimer's disease.。
Their findings provide further evidence that there might be a link between high blood sugar levels and the memory-robbing disease, though they don't prove that sugar causes Alzheimer's outright. 。
SEE ALSO:Doctors discover why stressed out people have more heart attacks 。"Excess sugar is well known to be bad for us when it comes to diabetes and obesity," said Omar Kassaar, a biologist at the University of Bath, in a press release. 。
"But this potential link with Alzheimer's disease is yet another reason that we should be controlling our sugar intake in our diets," he said.。
Alzheimer's is a progressive, degenerative disease that eventually hinders a person's ability to function. Along the way, the brain steadily erases all the names, faces, places and stories it's stored up over decades. Some people grow paranoid and depressed, or they stop eating and sleeping.。
In the U.S., Alzheimer's is the sixth-leading cause of death.。
With Alzheimer's, abnormal proteins accumulate into plaques and tangle between the brain's nerve cells. This build-up progressively damages the brain and leads to severe cognitive decline. 。
Thanks for signing up!。
Previous research has shown that glucose -- the body's main source of sugar -- and its related breakdown products can damage proteins in the body's cells. This happens through a reaction called glycation: when a sugar molecule bonds to a protein, without the controlling action of an enzyme.。
But scientists have lacked an understanding of the specific molecular link between glucose and Alzheimer's. That is, until now.。
This week, Kassaar and his colleagues from the University of Bath and King's College London said they've unraveled that link -- a discovery that could lead to new treatments or prevention measures for the brain disease, they said.。 In the study, which was published Thursday in the journal 。In the study, which was published Thursday in the journal。
, the researchers looked at brain samples from people with and without Alzheimer's.。
Left to right: Dr. Rob WIlliams, Dr. Omar Kassar and Prof. Jean van den Elsen in the lab at the University of Bath.Credit: ap commercial photography 。
They used a sensitive technique to detect the process of glycation. The researchers saw that, in the early stages of Alzheimer's, glycation damages an enzyme called MIF, or macrophage migration inhibitory factor. 。
MIF plays a role in insulin regulation and immune response. By inhibiting and reducing MIF, glycation seemed to hinder the brain cell's response to the accumulation of abnormal proteins. 。
The U.K. team found that as Alzheimer's progresses, glycation of the MIF enzymes increases. That makes MIF the likely "tipping point" in disease progression, according to their study.。
"Normally MIF would be part of the immune response to the build-up of abnormal proteins in the brain," Jean van den Elsen, a co-author and professor in the University of Bath's biology and biochemistry department, said in the press release. 。
Featured Video For You。
Tesla's rumored P100D could make Ludicrous mode even more Ludicrous2025-04-26 20:44
Apple snuck a weed joke into its developer conference presentation2025-04-26 20:43
Students create impressive schoolwork waterfall to celebrate the end of the year2025-04-26 20:22
'Minecraft' players on the autism spectrum find a safe space on the Autcraft server2025-04-26 20:17
Snapchat is about to explode in popularity, report says2025-04-26 20:00
'Minecraft' will be the second game ever to support cross2025-04-26 19:52
Apple's answer to the Amazon Echo could be unveiled as early as June2025-04-26 19:51
Trump is back from Europe and ready to ruin Twitter again2025-04-26 18:57
Singapore rolls out video2025-04-26 18:53
Intel study: self2025-04-26 18:14
Here's George Takei chilling in zero gravity for the 'Star Trek' anniversary2025-04-26 20:40
China debuts driverless train that only needs white painted lines as tracks2025-04-26 20:15
Stuck subway passengers throw impromptu graduation for student missing his ceremony2025-04-26 20:11
Justin Trudeau casually kayaks over to talk to his constituents2025-04-26 20:06
Daughter gives her 1002025-04-26 19:21
Louisiana Congressman on 'radicalized Islamic' suspects: 'kill them all'2025-04-26 19:05
Heat scorches eastern U.S. as snow (yes, snow) falls in California2025-04-26 18:57
The internet memes the crap out of the 'Murder on the Orient Express' trailer2025-04-26 18:33
Mall builds real2025-04-26 18:32
A new Android attack with a cool name can wreak havoc on your phone2025-04-26 18:06